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<title>Transaldolase</title>

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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Transaldolase</span></h1>

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<th colspan="3" style="background:#90EE90; color:#202122;">Transaldolase

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<p>Vorhandene Strukturdaten: <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1f05">1f05</a></span>

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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins

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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>

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<td colspan="2" style="text-align:center;">337 Aminosäuren

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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner

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<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=11559">TALDO1</a></i>

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<td>Externe IDs

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<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P37837">P37837</a></li></ul>

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<th colspan="3" style="background:#90EE90; color:#202122;">Enzymklassifikation

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<td><a href="EC-Nummer" title="EC-Nummer">EC, Kategorie</a>

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<td colspan="2" class="" style="text-align:center;"><a rel="nofollow" class="external text" href="https://www.brenda-enzymes.org/enzyme.php?ecno=2.2.1.2">2.2.1.2</a>, <a href="Transferase" title="Transferase">Transferase</a>

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<td>Reaktionsart

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<td colspan="2" style="text-align:center;">Übertragung eines CHOH-Rests

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<td>Substrat

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<td colspan="2" style="text-align:center;"><a href="Sedoheptulose-7-phosphat" title="Sedoheptulose-7-phosphat">Sedoheptulose-7-phosphat</a> + D-<a href="Glycerinaldehyd-3-phosphat" title="Glycerinaldehyd-3-phosphat">Glycerinaldehyd-3-phosphat</a>

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<td>Produkte

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<td colspan="2" style="text-align:center;">D-<a href="Erythrose-4-phosphat" title="Erythrose-4-phosphat">Erythrose-4-phosphat</a> + D-<a href="Fructose-6-phosphat" title="Fructose-6-phosphat">Fructose-6-phosphat</a>

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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen

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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie

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<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P37837">Transaldolase</a>

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<td style="background:#C3FDB8; color:#202122;">Übergeordnetes <a href="Taxon" title="Taxon">Taxon</a>

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<td colspan="2" style="text-align:center;">Lebewesen

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</p><p><b>Transaldolase (TAL)</b> (Gen: <i>TALDO1</i>) heißt das <a href="Enzym" title="Enzym">Enzym</a>, welches die Übertragung eines C3-Körpers von Sedoheptulose-7-phosphat auf <small>D</small>-<a href="Glycerinaldehyd-3-phosphat" title="Glycerinaldehyd-3-phosphat">Glycerinaldehyd-3-phosphat</a> und umgekehrt ermöglicht. Dieses Reaktionsgleichgewicht ist ein wichtiger Teil des <a href="Pentosephosphatweg" title="Pentosephosphatweg">Pentosephosphatwegs</a> in allen Lebewesen.

</p><p><a href="Mutation" title="Mutation">Mutationen</a> können die (seltene) <a href="Erbkrankheit" title="Erbkrankheit">Erbkrankheit</a> <b>Transaldolasemangel</b> bedingen.

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<div class="mw-heading mw-heading2"><h2 id="Katalysiertes_Gleichgewicht">Katalysiertes Gleichgewicht</h2></div>

<td><small>D</small>-<a href="Erythrose-4-phosphat" title="Erythrose-4-phosphat">Erythrose-4-phosphat</a></td>

<td><small>D</small>-<a href="Fructose-6-phosphat" title="Fructose-6-phosphat">Fructose-6-phosphat</a>

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<td><small>D</small>-<a href="Glycerinaldehyd-3-phosphat" title="Glycerinaldehyd-3-phosphat">Glycerinaldehyd-3-phosphat</a>

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<td>+

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<td><small>D</small>-<a href="Sedoheptulose-7-phosphat" title="Sedoheptulose-7-phosphat">Sedoheptulose-7-phosphat</a>

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<div class="mw-heading mw-heading2"><h2 id="Physiologische_Wirkungen">Physiologische Wirkungen</h2></div>

<p>Die Regulation der <a href="Genexpression" title="Genexpression">Genexpression</a> im <i>TALDO1</i>-<a href="Gen" title="Gen">Gen</a> kann den <a href="Glutathion" title="Glutathion">Glutathionspiegel</a> und die Sensitivität von Zellen für <a href="Apoptose" title="Apoptose">Apoptose</a> beeinflussen.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>

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<div class="mw-heading mw-heading2"><h2 id="Erkrankungen">Erkrankungen</h2></div>

<p>Manche <a href="Multiple_Sklerose" title="Multiple Sklerose">multiple-Sklerose</a>-Patienten besitzen <a href="Antik%C3%B6rper" title="Antikörper">Antikörper</a> gegen Bereiche der Transaldolase.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>

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<div class="mw-heading mw-heading3"><h3 id="Transaldolasemangel">Transaldolasemangel</h3></div>

<p>Mutationen im <i>TALDO1</i>-Gen können zur (seltenen) Erbkrankheit des Transaldolasemangels und dieser zu <a href="Leberzirrhose" title="Leberzirrhose">Leberzirrhose</a> führen.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Auch <a href="Multiorganversagen" title="Multiorganversagen">Multiorganversagen</a> kann bei Transaldolasemangel auftreten.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>

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<div class="mw-heading mw-heading3"><h3 id="Andere_Gendefekte">Andere Gendefekte</h3></div>

<p>Varianten des Enzyms sind möglicherweise mit <a href="Plattenepithelkarzinom" title="Plattenepithelkarzinom">Plattenepithelkarzinom</a> assoziiert.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>

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<div class="mw-heading mw-heading2"><h2 id="Anwendung">Anwendung</h2></div>

<p>Unterscheidungen des <a href="Bakterien" title="Bakterien">bakteriellen</a> Transaldolase-Gens mittels <a href="Polymerase-Kettenreaktion" title="Polymerase-Kettenreaktion">Polymerase-Kettenreaktion</a> werden genutzt, eine <a href="Darmflora" title="Darmflora">Darmbesiedelung</a> durch <a href="Bifidobacterium" title="Bifidobacterium">Bifidobacterium</a> zu identifizieren und zu quantifizieren.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup>

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<div class="mw-heading mw-heading2"><h2 id="Weblinks">Weblinks</h2></div>

<div class="sisterproject" style="margin:0.1em 0 0 0;"><div class="noviewer" style="display:inline-block; line-height:10px; min-width:1.6em; text-align:center;" aria-hidden="true" role="presentation"><span class="mw-default-size" typeof="mw:File"><span title="Wikibooks"></span></span></div><b><a href="https://de.wikibooks.org/wiki/Biochemie_und_Pathobiochemie:_Hexosemonophosphatweg" class="extiw external" title="b:Biochemie und Pathobiochemie: Hexosemonophosphatweg">Wikibooks: Biochemie und Pathobiochemie: Hexosemonophosphatweg</a></b> – Lern- und Lehrmaterialien</div>

<ul><li>[ reactome.org: <a rel="nofollow" class="external free" href="https://reactome.org/content/detail/R-HSA-71334">https://reactome.org/content/detail/R-HSA-71334</a> <i>sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate ⇔ D-erythrose 4-phosphate + D-fructose 6-phosphate</i>]</li></ul>

<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>

<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">Katalin Banki, Eliza Hutter, Emanuela Colombo, Nick J. Gonchoroff, Andras Perl: <i>Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression.</i> In: <i>Journal of Biological Chemistry</i>. Band 271, Nr. 51, 1996, S. 32994–33001, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1074/jbc.271.51.32994">10.1074/jbc.271.51.32994</a></span>.</span>

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<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">Niland B, Banki K, Biddison WE, Perl A: <cite style="font-style:italic">CD8+ T cell-mediated HLA-A*0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple sclerosis</cite>. In: <cite style="font-style:italic">J. Immunol.</cite> 175. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>12</span>, Dezember 2005, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>8365–8378</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/16339578?dopt=Abstract">PMID 16339578</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Transaldolase&rft.atitle=CD8%2B+T+cell-mediated+HLA-A%2A0201-restricted+cytotoxicity+to+transaldolase+peptide+168-176+in+patients+with+multiple+sclerosis&rft.au=Niland+B%2C+Banki+K%2C+Biddison+WE%2C+...&rft.date=2005-12&rft.genre=journal&rft.issue=12&rft.jtitle=J.+Immunol.&rft.pages=8365-8378&rft.pmid=16339578&rft.volume=175.+Jahrgang" style="display:none"> </span></span>

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<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">Nanda M. Verhoeven, Jojanneke H.J. Huck, Birthe Roos, Eduard A. Struys, Gajja S. Salomons, Adriaan C. Douwes, Marjo S. van der Knaap, Cornelis Jakobs: <i>Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway.</i> In: <i>The American Journal of Human Genetics</i>. Band 68, Nr. 5, 2001, S. 1086–1092, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1086/320108">10.1086/320108</a></span>.</span>

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<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">Vassili Valayannopoulos, Nanda M. Verhoeven, Karine Mention, Gajja S. Salomons, Danièle Sommelet, Marie Gonzales, Guy Touati, Pascale de Lonlay, Cornelis Jakobs, Jean-Marie Saudubray: <i>Transaldolase deficiency: a new cause of hydrops fetalis and neonatal multi-organ disease.</i> In: <i>The Journal of Pediatrics</i>. Band 149, Nr. 5, 2006, S. 713–717, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.jpeds.2006.08.016">10.1016/j.jpeds.2006.08.016</a></span>.</span>

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<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text"><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P37837">P37837</a></span>

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<li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text">Qian Y, Banerjee S, Grossman CE, <i>et al</i>: <cite style="font-style:italic">Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing</cite>. In: <cite style="font-style:italic">Biochem. J.</cite> 415. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, Oktober 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>123–34</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1042/BJ20080722">10.1042/BJ20080722</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18498245?dopt=Abstract">PMID 18498245</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Transaldolase&rft.atitle=Transaldolase+deficiency+influences+the+pentose+phosphate+pathway%2C+mitochondrial+homoeostasis+and+apoptosis+signal+processing&rft.au=Qian+Y%2C+Banerjee+S%2C+Grossman+CE%2C+...&rft.date=2008-10&rft.doi=10.1042%2FBJ20080722&rft.genre=journal&rft.issue=1&rft.jtitle=Biochem.+J.&rft.pages=123-34&rft.pmid=18498245&rft.volume=415.+Jahrgang" style="display:none"> </span></span>

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<li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text">Basta PV, Bensen JT, Tse CK, Perou CM, Sullivan PF, Olshan AF: <cite style="font-style:italic">Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck</cite>. In: <cite style="font-style:italic">Cancer Detect. Prev.</cite> 32. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>3</span>, 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>200–208</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.cdp.2008.08.008">10.1016/j.cdp.2008.08.008</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18805652?dopt=Abstract">PMID 18805652</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Transaldolase&rft.atitle=Genetic+variation+in+Transaldolase+1+and+risk+of+squamous+cell+carcinoma+of+the+head+and+neck&rft.au=Basta+PV%2C+Bensen+JT%2C+Tse+CK%2C+...&rft.date=2008&rft.doi=10.1016%2Fj.cdp.2008.08.008&rft.genre=journal&rft.issue=3&rft.jtitle=Cancer+Detect.+Prev.&rft.pages=200-208&rft.pmid=18805652&rft.volume=32.+Jahrgang" style="display:none"> </span></span>

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<li id="cite_note-8"><span class="mw-cite-backlink"><a href="#cite_ref-8">↑</a></span> <span class="reference-text">Teresa Requena, Jeremy Burton, Takahiro Matsuki, Karen Munro, Mary Alice Simon, Ryuichiro Tanaka, Koichi Watanabe, Gerald W. Tannock: <i>Identification, detection, and enumeration of human Bifidobacterium species by PCR targeting the transaldolase gene.</i> In: <i>Applied and Environmental Microbiology</i>. Band 68, Nr. 5, 2002, S. 2420–2427, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1128/AEM.68.5.2420-2427.2002">10.1128/AEM.68.5.2420-2427.2002</a></span>.</span>

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